PR5-LL-CM01
Product Specifications
UNSPSC Description
PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor (IC50= 7.5 μM). Anti-tumor activies[1].
Target Antigen
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pr5-ll-cm01.html
Purity
98.45
Solubility
DMSO : 11.11 mg/mL (ultrasonic;warming;adjust pH to 3 with HCl;heat to 80°C)
Smiles
CC1=CC=C(NC2=C3C(N(C4=CC=CC=C4)N=C3)=NC(NCCN(C)C)=N2)C=C1C
Molecular Weight
401.51
References & Citations
[1]Prabhu L, et al. Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers. Oncotarget. 2017;8(25):39963-39977.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-109963/PR5-LL-CM01-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-109963/PR5-LL-CM01-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1005307-86-7
Available Sizes
Curated Selection
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