PR5-LL-CM01

PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor (IC50= 7.5 μM) . Anti-tumor activies[1].

Product Specifications

CAS Number

[1005307-86-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pr5-ll-cm01.html

Purity

98.37

Solubility

DMSO : 11.11 mg/mL (ultrasonic; warming; adjust pH to 3 with HCl; heat to 80°C)

Smiles

CC1=CC=C(NC2=C3C(N(C4=CC=CC=C4)N=C3)=NC(NCCN(C)C)=N2)C=C1C

Molecular Formula

C23H27N7

Molecular Weight

401.51

Precautions

H302, H315, H319

References & Citations

[1]Prabhu L, et al. Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers. Oncotarget. 2017;8 (25) :39963-39977.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PRMT5

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

NBP2-80095DL594 0.1 mL

Rat Monoclonal Caspase-2 Antibody (10C6) [DyLight 594]

Ask

View Details

RK04670 96 Tests

Mouse IL-17A Fast ELISA Kit

Ask

View Details

UB-GEN-16418 100 µL

Contactin 5 Polyclonal Antibody

Ask

View Details

GTR15335444 1 Vial

Lentiviral human RSPH9 shRNA (UAS) - Lentiviral human RSPH9 shRNA (UAS) (25)

Ask

View Details

E53P01010 100 µL

Adiponectin Receptor 1 Rabbit Polyclonal Antibody

Ask

View Details