Ditercalinium (chloride)
Product Specifications
UNSPSC Description
Ditercalinium chloride is an anticancer agent. Ditercalinium chloride inhibits human DNA polymerase gamma activity. Ditercalinium chloride can deplete mitochondrial DNA in both mouse and human cells. Ditercalinium chloride is a potential ligand against the COMMD10-AP3S1 fusion protein[1][2].
Target Antigen
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ditercalinium-chloride.html
Purity
96.12
Solubility
DMSO : 2 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
COC1=CC2=C(NC3=C2C4=C[N+](CCN5CCC(C6CCN(CC[N+]7=CC=C8C=CC(NC9=C%10C=C(OC)C=C9)=C%10C8=C7)CC6)CC5)=CC=C4C=C3)C=C1.[Cl-].[Cl-]
Molecular Weight
789.83
References & Citations
[1]Okamaoto M, et al. Ditercalinium chloride, a pro-anticancer drug, intimately associates with mammalian mitochondrial DNA and inhibits its replication. Curr Genet. 2003 Aug;43(5):364-70. |[2]Sandhya Rai, et al. Ditercalinium chloride: A potential inhibitor targeting recurrent in frame COMMD10-AP3S1 fusions in CRCs. Gene Reports. 2023, 30:101739.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-19587/Ditercalinium-chloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-19587/Ditercalinium-chloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
74517-42-3
Available Sizes
Curated Selection
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