Azumolene (sodium)

Azumolene sodium (EU4093) is an analog of Dantrolene (HY-12542) that inhibits malignant hyperthermia (MH) syndrome and intracellular Ca2+ homeostasis failure caused by Halothane (HY-B1010) /Succinylcholine. Azumolene sodium (0.5-2.0 mg/kg) reduces [Ca2+]i (from 207 nM to 38 nM) in MH-susceptible skeletal muscle following intramuscular injection[1].

Product Specifications

CAS Number

[105336-14-9]

Product Name Alternative

EU4093

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/azumolene-sodium.html

Solubility

10 mM in DMSO

Smiles

O=C1NC(CN1/N=C/C2=NC=C(C3=CC=C(Br)C=C3)O2)=O.[Na]

Molecular Formula

C13H9BrN4NaO3

Molecular Weight

372.13

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Allen P D, Lopez J R, Sanchez V, et al. EU 4093 decreases intracellular [Ca2+] in skeletal muscle fibers from control and malignant hyperthermia-susceptible swine[J]. Anesthesiology, 1992, 76 (1) : 132-138.