SMS2-IN-1
SMS2-IN-1 is a potent and highly selective sphingomyelin synthase 2 (SMS2) inhibitor with an IC50 of 6.5 nM and a Kd of 37 nM. SMS2-IN-1 shows 150-fold selectivity for SMS2 over SMS1 (IC50 of 1000 nM) [1].
Product Specifications
CAS Number
[2098890-15-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/SMS2-IN-1.html
Purity
98.04
Solubility
DMSO : 27.78 mg/mL (ultrasonic)
Smiles
O=C1C(C(N(CC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C)=O)=C(OCCCC3CCN(C(OC4(CC4)C)=O)CC3)C5=CC=CC=C5N1C
Molecular Formula
C34H37F6N3O5
Molecular Weight
681.67
Precautions
H302, H315, H319, H335
References & Citations
[1]Adachi R, et al. Discovery and characterization of selective human sphingomyelin synthase 2 inhibitors. Eur J Med Chem. 2017 Aug 18;136:283-293.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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