YZ9
Y29 is a potent PFKFB3 inhibitor with an IC50 of 0.183 µM, and acts as a competitive inhibitor against Fru-6-P with a Ki value of 0.094 µM. Y29 exhibits antitumor effects against cervical cancer[1].
Product Specifications
CAS Number
6093-71-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/yz9.html
Concentration
10mM
Purity
99.20
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1OC2=CC(O)=CC=C2C=C1C(OCC)=O
Molecular Formula
C12H10O5
Molecular Weight
234.21
Precautions
H302, H315, H319, H335
References & Citations
[1]Minsuh Seo, et al. Structure-based development of small molecule PFKFB3 inhibitors: a framework for potential cancer therapeutic agents targeting the Warburg effect. PLoS One. 2011;6 (9) :e24179.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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