TCO-PEG12-NHS ester
Product Specifications
UNSPSC Description
TCO-PEG12-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG12-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. TCO-PEG12-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
Target Antigen
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tco-peg12-nhs-ester.html
Solubility
10 mM in DMSO
Smiles
O=C(OC1CC/C=C\CCC1)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O
Molecular Weight
866.99
References & Citations
[1]Leon S. FARHI, et al. Compositions and methods for high-sensitivity immunoassays. WO2018027221A1
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-141170/TCO-PEG12-NHS-ester-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-141170/TCO-PEG12-NHS-ester-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2185016-39-9
Available Sizes
Curated Selection
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