MPP+-d3 (iodide)
MPP+-d3 (iodide) is deuterium labeled MPP+ (iodide) . MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT) [1][2].
Product Specifications
CAS Number
207556-07-8
UNSPSC
12352005
Hazard Statement
H301, H311, H315, H319, H331, H335
Target
Mitochondrial Metabolism
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
99.21
Solubility
DMSO : 100mg/mL (ultrasonic)
Smiles
[2H]C([2H])([2H])[N+]1=CC=C(C2=CC=CC=C2)C=C1.[I-]
Molecular Formula
C12H9D3IN
Molecular Weight
300.15
Precautions
H301, H311, H315, H319, H331, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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