Kevetrin (hydrochloride)
Kevetrin hydrochloride is a potent activator of p53, induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells. Kevetrin a preferential cytotoxic activity against blast cells[1][2].
Product Specifications
CAS Number
66592-89-0
Product Name Alternative
4-Isothioureidobutyronitrile hydrochloride; thioureidobutyronitrile hydrochloride; thioureido butyronitrile hydrochloride
UNSPSC
12352211
Hazard Statement
H302
Target
Apoptosis; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Kevetrin-hydrochloride.html
Purity
98.0
Solubility
DMSO : ≥ 40 mg/mL|H2O : 100 mg/mL (ultrasonic)
Smiles
NC(SCCCC#N)=N.[H]Cl
Molecular Formula
C5H10ClN3S
Molecular Weight
179.67
Precautions
H302
References & Citations
[1]Napolitano R, et al. Kevetrin induces apoptosis in TP53 wildtype and mutant acute myeloid leukemia cells. Oncol Rep. 2020 Oct;44 (4) :1561-1573. |[2]Kumar A, et al. Abstract 3221: kevetrin induces p53-dependent and independKumar A, et al. Abstract 3221: kevetrin induces p53-dependent and independent cell cycle arrest and apoptosis in ovarian cancer cell lines representing heterogeneous histologies. Cancer Research. 2017. 77 (13 Supplement), 3221-3221.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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