Kevetrin (hydrochloride)

Kevetrin hydrochloride is a potent activator of p53, induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells. Kevetrin a preferential cytotoxic activity against blast cells[1][2].

Product Specifications

CAS Number

[66592-89-0]

Product Name Alternative

4-Isothioureidobutyronitrile hydrochloride; thioureidobutyronitrile hydrochloride; thioureido butyronitrile hydrochloride

UNSPSC

12352211

Hazard Statement

H302

Target

Apoptosis; MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Kevetrin-hydrochloride.html

Purity

98.0

Solubility

DMSO : ≥ 40 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

NC(SCCCC#N)=N.[H]Cl

Molecular Formula

C5H10ClN3S

Molecular Weight

179.67

Precautions

H302

References & Citations

[1]Napolitano R, et al. Kevetrin induces apoptosis in TP53 wildtype and mutant acute myeloid leukemia cells. Oncol Rep. 2020 Oct;44 (4) :1561-1573. |[2]Kumar A, et al. Abstract 3221: kevetrin induces p53-dependent and independKumar A, et al. Abstract 3221: kevetrin induces p53-dependent and independent cell cycle arrest and apoptosis in ovarian cancer cell lines representing heterogeneous histologies. Cancer Research. 2017. 77 (13 Supplement), 3221-3221.