Pergolide (mesylate)

Pergolide mesylate (Pergolide methanesulfonate), an Ergoline derivative, is a potent and orally active dopamine D1 and D2 receptors agonist. Pergolide mesylate can be used for Parkinson's disease and hyperprolactinaemia research[1][2].

Product Specifications

CAS Number

[66104-23-2]

Product Name Alternative

Pergolide methanesulfonate; LY127809

UNSPSC

12352005

Hazard Statement

H300

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pergolide-mesylate.html

Purity

99.98

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

[H][C@@]1(N(CCC)C[C@H](CSC)C[C@@]12[H])CC3=CNC4=CC=CC2=C43.CS(=O)(O)=O

Molecular Formula

C20H30N2O3S2

Molecular Weight

410.59

Precautions

H300

References & Citations

[1]S Franks, et al. Effectiveness of pergolide mesylate in long term treatment of hyperprolactinaemia. Br Med J (Clin Res Ed) . 1983 Apr 9;286 (6372) :1177-9.|[2]Daniela Uberti, et al. Pergolide protects SH-SY5Y cells against neurodegeneration induced by H (2) O (2) . Eur J Pharmacol. 2002 Jan 2;434 (1-2) :17-20.|[3]Alin Ciobica, et al. The effects of pergolide on memory and oxidative stress in a rat model of Parkinson's disease. J Physiol Biochem. 2012 Mar;68 (1) :59-69.