RU 24969 (succinate)

RU 24969 succinate is a 5-HT receptor agonist with Ki values of 0.38 and 2.5 nM for 5-HT1B and 5-HT1A, respectively. RU 24969 decreases fluid consumption and increases forward locomotion. RU 24969 succinate can be used for the research of neurological disease[1][2][3][4].

Product Specifications

CAS Number

[107008-28-6]

UNSPSC

12352005

Hazard Statement

H302-H317

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ru-24969-succinate.html

Purity

99.58

Solubility

DMSO : 120 mg/mL (ultrasonic)

Smiles

O=C(O)CCC(O)=O.COC1=CC=C2C(C(C3=CCNCC3)=CN2)=C1

Molecular Formula

C18H22N2O5

Molecular Weight

346.38

Precautions

P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501

References & Citations

[1]Middlemiss DN. The putative 5-HT1 receptor agonist, RU 24969, inhibits the efflux of 5-hydroxytryptamine from rat frontal cortex slices by stimulation of the 5-HT autoreceptor. J Pharm Pharmacol. 1985 Jun;37 (6) :434-7.|[2]Parsons LH, et al. RU 24969, a 5-HT1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine. Synapse. 1999 May;32 (2) :132-5.|[3]Peroutka SJ. Pharmacological differentiation and characterization of 5-HT1A, 5-HT1B, and 5-HT1C binding sites in rat frontal cortex. J Neurochem. 1986 Aug;47 (2) :529-40.|[4]Aronsen D, et al. RU 24969-produced adipsia and hyperlocomotion: differential role of 5HT 1A and 5HT 1B receptor mechanisms. Pharmacol Biochem Behav. 2014 Sep;124:1-4.