Pristinamycin

Pristinamycin, produced by Streptomyces pristinaespiralis, is an orally active streptogramin-like antibiotic consisting of two chemically unrelated components: Pristinamycin I (PI) and Pristinamycin II (PII) . Pristinamycin is highly active against many antibiotic-resistant pathogens, particularly Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant S. aureus (VRSA) and Enterococcus faecium (VREF) [1].

Product Specifications

CAS Number

[270076-60-3]

Product Name Alternative

Pristinamycine

UNSPSC

12352005

Target

Antibiotic; Bacterial

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/pristinamycin.html

Purity

99.63

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H]1C(N[C@H](CC)C(N2[C@](CCC2)([H])C(N(C)[C@@H](CC3=CC=C(N(C)C)C=C3)C(N4[C@](CC(CC4)=O)([H])C(N[C@@H](C5=CC=CC=C5)C(O[C@@H]1C)=O)=O)=O)=O)=O)=O)C6=NC=CC=C6O.O=C7N8C(C(O[C@@H]([C@@H](/C=C/C(NC/C=C/C(C)=C/[C@H](CC(CC9=NC7=CO9)=O)O)=O)C)C(C)C)=O)=CCC8

Molecular Formula

C73H89N11O17

Molecular Weight

1392.55

References & Citations

[1]Meng J, et al. Improvement of pristinamycin I (PI) production in Streptomyces pristinaespiralis by metabolic engineering approaches. Synth Syst Biotechnol. 2017;2 (2) :130-136. Published 2017 Jun 8.|[2]Maskell JP, et al. Comparative in-vitro activity of erythromycin, vancomycin and pristinamycin. Infection. 1988;16 (6) :365-370.|[3]Orfila J, Haider F. Action de la pristinamycine sur les Chlamydia [Action of pristinamycin on Chlamydia]. Pathol Biol (Paris) . 1984;32 (5) :443-445.