AMPK-IN-5
Product Specifications
UNSPSC Description
AMPK-IN-5 (compound 7m) is a Osthole (HY-N0054) derivative, and blocks MAPK signal transduction by inhibiting the phosphorylation of JNK and p38, thereby inhibiting the release of inflammatory cytokines. AMPK-IN-5 reduce DSS-induced ulcerative colitis and LPS (HY-D1056)-induced acute lung injury[1].
Target Antigen
JAK; p38 MAPK
Type
Reference compound
Related Pathways
Epigenetics;JAK/STAT Signaling;MAPK/ERK Pathway;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ampk-in-5.html
Solubility
10 mM in DMSO
Smiles
O=C1C=CC2=C(C(C/C=C(C)/C)=C(OCCCCNCCN3CCOCC3)C=C2)O1
Molecular Weight
414.54
References & Citations
[1]Zhou Y, et al. Discovery of novel osthole derivatives exerting anti-inflammatory effect on DSS-induced ulcerative colitis and LPS-induced acute lung injury in mice. Eur J Med Chem. 2024 Feb 22;268:116252.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162317/AMPK-IN-5-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162317/
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Chromogranin A (CHGA) Mouse Monoclonal Antibody [Clone ID: OTI1A3]](https://cdn.genprice.uk/genprice/genprice2.png)
