AMPK-IN-5
AMPK-IN-5 (compound 7m) is a Osthole derivative, and blocks MAPK signal transduction by inhibiting the phosphorylation of JNK and p38, thereby inhibiting the release of inflammatory cytokines. AMPK-IN-5 reduce DSS-induced ulcerative colitis and LPS (HY-D1056) -induced acute lung injury[1].
Product Specifications
UNSPSC
12352005
Target
JAK; p38 MAPK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ampk-in-5.html
Solubility
10 mM in DMSO
Smiles
O=C1C=CC2=C(C(C/C=C(C)/C)=C(OCCCCNCCN3CCOCC3)C=C2)O1
Molecular Formula
C24H34N2O4
Molecular Weight
414.54
References & Citations
[1]Zhou Y, et al. Discovery of novel osthole derivatives exerting anti-inflammatory effect on DSS-induced ulcerative colitis and LPS-induced acute lung injury in mice. Eur J Med Chem. 2024 Feb 22;268:116252.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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