AMPK-IN-5

AMPK-IN-5 (compound 7m) is a Osthole (HY-N0054) derivative, and blocks MAPK signal transduction by inhibiting the phosphorylation of JNK and p38, thereby inhibiting the release of inflammatory cytokines. AMPK-IN-5 reduce DSS-induced ulcerative colitis and LPS (HY-D1056) -induced acute lung injury[1].

Product Specifications

UNSPSC

12352005

Target

JAK; p38 MAPK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ampk-in-5.html

Solubility

10 mM in DMSO

Smiles

O=C1C=CC2=C(C(C/C=C(C)/C)=C(OCCCCNCCN3CCOCC3)C=C2)O1

Molecular Formula

C24H34N2O4

Molecular Weight

414.54

References & Citations

[1]Zhou Y, et al. Discovery of novel osthole derivatives exerting anti-inflammatory effect on DSS-induced ulcerative colitis and LPS-induced acute lung injury in mice. Eur J Med Chem. 2024 Feb 22;268:116252.