β-Lapachone
Product Specifications
UNSPSC Description
β-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.
Target Antigen
Apoptosis; Autophagy; Indoleamine 2,3-Dioxygenase (IDO); Topoisomerase
Type
Natural Products
Related Pathways
Apoptosis;Autophagy;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/_beta_-Lapachone.html
Smiles
O=C(C1=C2OC(C)(C)CC1)C(C3=C2C=CC=C3)=O
Molecular Weight
242.27
References & Citations
[1]Li CJ, et al. beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin. J Biol Chem. 1993 Oct 25;268(30):22463-8.|[2]Vanni A, et al. DNA damage and cytotoxicity induced by beta-lapachone: relation to poly(ADP-ribose) polymerase inhibition. Mutat Res. 1998 Jun 5;401(1-2):55-63.|[3]Kim TW, et al. β-Lapachone enhances Mre11-Rad50-Nbs1 complex expression in cisplatin-induced nephrotoxicity. Pharmacol Rep. 2016 Feb;68(1):27-31.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13555/β-Lapachone-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13555/β-Lapachone-SDS-MedChemExpress.pdf
CAS Number
4707-32-8
Available Sizes
Curated Selection
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