ACY-957
ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9[1].
Product Specifications
CAS Number
1609389-52-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ACY-957.html
Purity
99.63
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C2N=C(N3CCNCC3)C=CC2=C1)NC4=CC(C5=CC=CS5)=CC=C4N
Molecular Formula
C24H23N5OS
Molecular Weight
429.54
Precautions
H302, H315, H319
References & Citations
[1]Shearstone JR, et al. Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2. PLoS One. 2016 Apr 13;11 (4) :e0153767.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC3
Available Sizes
Frequently Asked Questions
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