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ACY-957

ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9[1].

Product Specifications

CAS Number

1609389-52-7

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ACY-957.html

Purity

99.63

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C2N=C(N3CCNCC3)C=CC2=C1)NC4=CC(C5=CC=CS5)=CC=C4N

Molecular Formula

C24H23N5OS

Molecular Weight

429.54

Precautions

H302, H315, H319

References & Citations

[1]Shearstone JR, et al. Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2. PLoS One. 2016 Apr 13;11 (4) :e0153767.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HDAC1; HDAC2; HDAC3

Available Sizes

Frequently Asked Questions

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