Riddelline

Riddelline, a pyrrolizidine alkaloid, is a potent genotoxic agent. Riddelline induces significant elevations in unscheduled DNA synthesis and S-phase synthesis in rat liver[1].

Product Specifications

CAS Number

[23246-96-0]

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/riddelline.html

Solubility

10 mM in DMSO

Smiles

O=C(/C(CC([C@]1(O)CO)=C)=C\C)O[C@@]2([H])[C@@]3([H])C(COC1=O)=CCN3CC2

Molecular Formula

C18H23NO6

Molecular Weight

349.38

References & Citations

[1]J C Mirsalis, et al. In Vivo Measurement of Unscheduled DNA Synthesis and S-phase Synthesis as an Indicator of Hepatocarcinogenesis in Rodents. 5.097Q1 Cell Biol Toxicol. 1987 Jun;3 (2) :165-73.