Fmoc-Gly-Gly-Phe-OtBu
Fmoc-Gly-Gly-Phe-OtBu is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
[236426-37-2]
UNSPSC
12352203
Hazard Statement
H302-H315-H319-H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fmoc-gly-gly-phe-otbu.html
Purity
99.80
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(OC(C)(C)C)[C@H](CC1=CC=CC=C1)NC(CNC(CNC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O)=O)=O
Molecular Formula
C32H35N3O6
Molecular Weight
557.64
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Bak A, et al. Synthesis and evaluation of the physicochemical properties of esterase-sensitive cyclic prodrugs of opioid peptides using an (acyloxy) alkoxy linker. J Pept Res. 1999 Apr;53 (4) :393-402.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker
Available Sizes
Curated Selection
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