L002
L002 is a potent, cell permeable, reversible and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 μM[1]. L002 binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain, blocks histone acetylation and p53 acetylation, and inhibits STAT3 activation[2]. L002 has the potential for hypertension-induced cardiac hypertrophy and fibrogenesis treatment[3].
Product Specifications
CAS Number
321695-57-2
UNSPSC
12352005
Target
Histone Acetyltransferase; STAT
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/l002.html
Purity
99.44
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C1C(C)=C/C(C=C1C)=N\OS(=O)(C2=CC=C(OC)C=C2)=O
Molecular Formula
C15H15NO5S
Molecular Weight
321.35
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBP/p300
Available Sizes
Frequently Asked Questions
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