Ibutamoren (Mesylate)

Ibutamoren Mesylate (MK-677) is a potent, non-peptide Growth hormone secretagogue receptor (GHSR) agonist. Ibutamoren Mesylate is an orally active growth hormone (GH) secretagogue.

Product Specifications

CAS Number

[159752-10-0]

Product Name Alternative

MK-677; MK-0677

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GHSR

Type

Reference compound

Related Pathways

GPCR/G Protein

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/ibutamoren-mesylate.html

Purity

99.86

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

CC(N)(C(N[C@@H](C(N1CCC2(CN(C3=C2C=CC=C3)S(=O)(C)=O)CC1)=O)COCC4=CC=CC=C4)=O)C.CS(=O)(O)=O

Molecular Formula

C28H40N4O8S2

Molecular Weight

624.77

Precautions

H302, H315, H319, H335

References & Citations

[1]Prahalada S, et al. Insulin-like growth factor-1 and growth hormone (GH) levels in canine cerebrospinal fluid are unaffected by GH or GH secretagogue (MK-0677) administration. Horm Metab Res. 1999 Feb-Mar;31 (2-3) :133-7.|[2]Zheng H, et al. Somatostatin receptor subtype 2 knockout mice are refractory to growth hormone-negative feedback on arcuate neurons. Mol Endocrinol. 1997 Oct;11 (11) :1709-17.|[3]Hickey GJ, et al. Repeat administration of the GH secretagogue MK-0677 increases and maintains elevated IGF-I levels in beagles. J Endocrinol. 1997 Feb;152 (2) :183-92.|[4]Jacks T, et al. MK-0677, a potent, novel, orally active growth hormone (GH) secretagogue: GH, insulin-like growth factor I, and other hormonal responses in beagles. Endocrinology. 1996 Dec;137 (12) :5284-9.