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Chlorprothixene (hydrochloride)

Chlorprothixene hydrochloride is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity[1].

Product Specifications

CAS Number

[6469-93-8]

UNSPSC

12352005

Hazard Statement

H301

Target

Bacterial; Dopamine Receptor; Histamine Receptor

Type

Reference compound

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/chlorprothixene-hydrochloride.html

Purity

99.91

Solubility

DMSO : 2.5 mg/mL (ultrasonic) |Ethanol : 25 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)

Smiles

CN(C)CC/C=C1C2=C(SC3=C\1C=CC=C3)C=CC(Cl)=C2.[H]Cl

Molecular Formula

C18H19Cl2NS

Molecular Weight

352.32

Precautions

H301

References & Citations

[1]Y von Coburg, et al. Potential utility of histamine H3 receptor antagonist pharmacophore in antipsychotics. Bioorg Med Chem Lett. 2009 Jan 15;19 (2) :538-42.|[2]B L Roth, et al. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther. 1994 Mar;268 (3) :1403-10.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

D1 Receptor; D2 Receptor; D3 Receptor; D5 Receptor; H1 Receptor

Available Sizes

Curated Selection

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