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Chlorprothixene (hydrochloride)

Product Specifications

UNSPSC Description

Chlorprothixene hydrochloride is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity[1].

Target Antigen

Bacterial; Dopamine Receptor; Histamine Receptor

Type

Reference compound

Related Pathways

Anti-infection;GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/chlorprothixene-hydrochloride.html

Purity

99.91

Solubility

DMSO : 2.5 mg/mL (ultrasonic)|Ethanol : 25 mg/mL (ultrasonic)|H2O : 25 mg/mL (ultrasonic)

Smiles

CN(C)CC/C=C1C2=C(SC3=C\1C=CC=C3)C=CC(Cl)=C2.[H]Cl

Molecular Weight

352.32

References & Citations

[1]Y von Coburg, et al. Potential utility of histamine H3 receptor antagonist pharmacophore in antipsychotics. Bioorg Med Chem Lett. 2009 Jan 15;19(2):538-42.|[2]B L Roth, et al. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther. 1994 Mar;268(3):1403-10.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-B0274A/Chlorprothixene-hydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-B0274A/Chlorprothixene-hydrochloride-SDS-MedChemExpress.pdf

Clinical Information

Launched

CAS Number

6469-93-8

Available Sizes

Curated Selection

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