Oleic-DBCO

Oleic-DBCO is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Oleic-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Product Specifications

CAS Number

[2279951-78-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/oleic-dbco.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O=C(N(C1)C2=C(C=CC=C2)C#CC3=C1C=CC=C3)CCNC(CCCCCCC/C=C\CCCCCCCC)=O

Molecular Formula

C36H48N2O2

Molecular Weight

540.78

Precautions

H302, H315, H319, H335

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562