Mosperafenib
Mosperafenib is a blood-brain barrier-permeable BRAF inhibitor. Mosperafenib can be used for the study of BRAF V600-mutant solid tumors, such as colorectal cancer (CRC) [1].
Product Specifications
CAS Number
2649372-20-1
Product Name Alternative
RG6344; RO7276389; B-Raf IN 2
UNSPSC
12352005
Hazard Statement
H302, H312, H315, H319, H332, H335
Target
Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/b-raf-in-2.html
Concentration
10mM
Purity
99.27
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC1=C(C(F)=CC=C1NS(=O)(N2C[C@@H](CC2)F)=O)OC3=CC=C(N=CN(C4=O)C)C4=C3
Molecular Formula
C20H17F2N5O4S
Molecular Weight
461.44
Precautions
H302, H312, H315, H319, H332, H335
References & Citations
[1]Maria Vieito, et al. Abstract CT017: A phase I study evaluating safety, pharmacokinetics, and clinical activity of the novel, paradox breaker BRAF inhibitor RG6344 in patients with BRAF V600-mutant solid tumors. Cancer Res (2025) 85 (8_Supplement_2) : CT017.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf
Available Sizes
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