Miricorilant
Miricorilant (CORT 118335) is a dual selective glucocorticoid (GR) modulator/mineralocorticoid (MR) antagonist. Miricorilant can be used for the research of hypothalamic-pituitary-adrenal (HPA) axis related disorders[1].
Product Specifications
CAS Number
1400902-13-7
Product Name Alternative
CORT 118335
UNSPSC
12352005
Target
Glucocorticoid Receptor; Mineralocorticoid Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/miricorilant.html
Solubility
10 mM in DMSO
Smiles
O=C1NC(C(CC2=CC=CC(C(F)(F)F)=C2)=C(N1)[C@H]3CC[C@@H](CC3)C4=CC=CC=C4)=O
Molecular Formula
C24H23F3N2O2
Molecular Weight
428.45
References & Citations
[1]Elizabeth T Nguyen, et al. A Mixed Glucocorticoid/Mineralocorticoid Receptor Modulator Dampens Endocrine and Hippocampal Stress Responsivity in Male Rats. Physiol Behav. 2017 Sep 1;178:82-92.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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