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Dihydromyricetin (Standard)

Dihydromyricetin (Standard) is the analytical standard of Dihydromyricetin. This product is intended for research and analytical applications. Dihydromyricetin is a potent inhibitor with an IC50 of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2) . Dihydromyricetin is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 22 μM.

Product Specifications

CAS Number

27200-12-0

Product Name Alternative

Ampelopsin (Standard) ; Ampeloptin (Standard)

UNSPSC

12352005

Target

Autophagy; DNA/RNA Synthesis; Influenza Virus; mTOR; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; Autophagy; Cell Cycle/DNA Damage; Others; PI3K/Akt/mTOR

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/dihydromyricetin-standard.html

Smiles

O=C1[C@H](O)[C@@H](C2=CC(O)=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C13

Molecular Formula

C15H12O8

Molecular Weight

320.25

References & Citations

[1]Huang CY. Inhibition of a Putative Dihydropyrimidinase from Pseudomonas aeruginosa PAO1 by Flavonoids and Substrates of Cyclic Amidohydrolases. PLoS One. 2015 May 19;10 (5) :e0127634.|[2]Kou X, et al. Ampelopsin attenuates brain aging of D-gal-induced rats through miR-34a-mediated SIRT1/mTORsignal pathway. Oncotarget. 2016 Nov 15;7 (46) :74484-74495.|[3]Chang H, et al. Ampelopsin suppresses breast carcinogenesis by inhibiting the mTOR signalling pathway. Carcinogenesis. 2014 Aug;35 (8) :1847-54.|[4]Václav Zima, et al. Unraveling the Anti-Influenza Effect of Flavonoids: Experimental Validation of Luteolin and its Congeners as Potent Influenza Endonuclease Inhibitors. Eur J Med Chem. 22 August 2020, 112754.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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