L-732138
L-732138 is a selective, potent and competitive neurokinin-1 (NK-1) receptor antagonist with an IC50 of 2.3 nM. L-732138 has 200-fold more potent in cloned human NK-1 receptors than cloned rat NK-1 receptors, and has > 1000-fold more potent than human NK-2 and NK-3 receptors. L-732138 can reduce hyperalgesia and has antitumor action[1][2].
Product Specifications
CAS Number
148451-96-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/l-732138.html
Concentration
10mM
Purity
99.9
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(OCC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)[C@H](CC2=CNC3=CC=CC=C23)NC(C)=O
Molecular Formula
C22H18F6N2O3
Molecular Weight
472.38
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NK1R
Available Sizes
Frequently Asked Questions
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