PDGFRα kinase inhibitor 1

PDGFRα kinase inhibitor 1 is a highly selective type II PDGFRα kinase inhibitor with IC50s of 132 nM and 6115 nM for PDGFRα and PDGFRβ, respectively[1].

Product Specifications

CAS Number

[2209053-93-8]

UNSPSC

12352005

Target

PDGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PDGFR_alpha__kinase_inhibitor_1.html

Purity

98.51

Solubility

DMSO : 260 mg/mL (ultrasonic)

Smiles

CC(C=CC(NC(C1=CC=C(CN(CCN(C)C)C(C2=CC=CN=C2)=O)C=C1)=O)=C3)=C3NC4=NC=CC(C5=CC=CN=C5)=N4

Molecular Formula

C34H34N8O2

Molecular Weight

586.69

References & Citations

[1]Wang Q, et al. Discovery of 4- ((N- (2- (dimethylamino) ethyl) acrylamido) methyl) -N- (4-methyl-3- ((4- (pyridin-3-yl) pyrimidin-2-yl) amino) phenyl) benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFRα kinase inhibitor for PDGFRα driving chronic eosinophilic leukemia. Eur J Med Chem. 2018 Apr 25;150:366-384.