Tyrphostin 23
Tyrphostin 23 (Tyrphostin A23) is an EGFR inhibitor with an IC50 and Kiof 35 and 11 μM, respectively.
Product Specifications
CAS Number
118409-57-7
Product Name Alternative
Tyrphostin A23; RG-50810; AG 18
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AG-18.html
Purity
98.19
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#C/C(C#N)=C/C1=CC=C(O)C(O)=C1
Molecular Formula
C10H6N2O2
Molecular Weight
186.17
Precautions
H302, H315, H319, H335
References & Citations
[1]Gazit A, et al. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem. 1989 Oct;32 (10) :2344-52.|[2]Nanzer AM, et al. Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway. Eur J Endocrinol. 2004 Aug;151 (2) :233-40.|[3]Hohnholt MC, et al. The tricarboxylic acid cycle activity in cultured primary astrocytes is strongly accelerated by the protein tyrosine kinase inhibitor tyrphostin 23. Neurochem Int. 2017 Jan;102:13-21.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1
Available Sizes
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