Tyrphostin 23

Tyrphostin 23 (Tyrphostin A23) is an EGFR inhibitor with an IC50 and Kiof 35 and 11 μM, respectively.

Product Specifications

CAS Number

[118409-57-7]

Product Name Alternative

Tyrphostin A23; RG-50810; AG 18

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AG-18.html

Purity

98.19

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#C/C(C#N)=C/C1=CC=C(O)C(O)=C1

Molecular Formula

C10H6N2O2

Molecular Weight

186.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Gazit A, et al. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem. 1989 Oct;32 (10) :2344-52.|[2]Nanzer AM, et al. Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway. Eur J Endocrinol. 2004 Aug;151 (2) :233-40.|[3]Hohnholt MC, et al. The tricarboxylic acid cycle activity in cultured primary astrocytes is strongly accelerated by the protein tyrosine kinase inhibitor tyrphostin 23. Neurochem Int. 2017 Jan;102:13-21.