Cletoquine (oxalate)

Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine oxalate is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine oxalate is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV) . Cletoquine oxalate has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].

Product Specifications

CAS Number

[14142-64-4]

Product Name Alternative

Desethylhydroxychloroquine (oxalate)

UNSPSC

12352005

Target

CHIKV; Influenza Virus; Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cletoquine-oxalate.html

Concentration

10mM

Purity

99.63

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCNCCO.O=C(O)C(O)=O

Molecular Formula

C18H24ClN3O5

Molecular Weight

397.85

References & Citations

[1]Kumar M, et al. Molecular docking studies of chloroquine and its derivatives against P23pro-zbd domain of chikungunya virus: Implication in designing of novel therapeutic strategies. J Cell Biochem. 2019 Oct;120 (10) :18298-18308.|[2]Charlier B, et al. Development of a novel ion-pairing HPLC-FL method for the separation and quantification of hydroxychloroquine and its metabolites in whole blood. Biomed Chromatogr. 2018 Aug;32 (8) :e4258.|[3]Chhonker YS, et al. Simultaneous quantitation of hydroxychloroquine and its metabolites in mouse blood and tissues using LC-ESI-MS/MS: An application for pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 1;1072:320-327.