Murine Osteoblast to Osteocyte-like Cell Line MLO-A5

MLO-A5 cell line is a model for the osteoblast to osteocyte differentiation process, the mineralization process, and the effects of mechanical loading on biomineralization.Derived from a transgenic mouse in which the immortalizing T-antigen was expressed under control of the osteocalcin promoter.Osteocytes are the most abundant bone cells in the body but also the most challenging to study because they are embedded in a mineralized matrix making them to difficult to isolate. This cell line MLO-A5 make it easier to study osteocyte function.