TRPM8 agonist WS-3

TRPM8 agonist WS-3 is an specific agonist of TRPM8 with an EC50 of 3.7 μM. TRPM8 agonist WS-3 inhibits epileptic seizures through a TRPM8 dependent mechanism. TRPM8 agonist WS-3 can be used for research on epilepsy and other conditions[1][2].

Product Specifications

CAS Number

[39711-79-0]

Product Name Alternative

Framidice 3

UNSPSC

12352211

Hazard Statement

H302, H319

Target

Endogenous Metabolite; TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/trpm8-agonist-ws-3.html

Concentration

10mM

Purity

99.35

Solubility

DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL

Smiles

CC(C)C1CCC(C)CC1C(NCC)=O

Molecular Formula

C13H25NO

Molecular Weight

211.35

Precautions

H302, H319

References & Citations

[1]Behrendt HJ, et al. Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol. 2004 Feb;141 (4) :737-45.|[2]Moriyama H, et al. Anti-seizure effects of WS-3, a TRPM8 agonist, on focal onset seizure mouse model via reduction of extracellular glutamate levels. Neuropsychopharmacology. 2025 Nov;50 (12) :1855-1863.