B104-1-1

Tissue: embryo; Transfected with EcoR1 digested DNA from the rat neuroblastoma B104; Original line: NIH/3T3. The cells contain the transforming gene neu which induces synthesis of a tumor antigen of relative molecular mass 185, 000 (p185), strongly associated with the presence of neuro/glioblastoma oncogenes. The neu oncogene bears homology to erb-B and the tumor antigen p185 is serologically related to the epidermal growth factor receptor.