FH1

FH1 (NSC 12407) is a NQO2 inhibitor with hepatoprotective effects. FH1 enhances hepatocyte function and promotes differentiation of induced pluripotent stem (iPS) -derived hepatocytes to a more mature phenotype and maturation of well-differentiated hepatocyte-like cell (iHeps) cultures. FH1 protects against Acetaminophen (HY-66005) -induced hepatotoxicity in both embryos and adult zebrafish[1][2][3].

Product Specifications

CAS Number

[2719-05-3]

Product Name Alternative

NSC 12407; BRD-K4477

UNSPSC

12352005

Hazard Statement

H400

Target

Quinone Reductase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/FH1.html

Purity

99.17

Solubility

DMSO : 13 mg/mL (ultrasonic; warming)

Smiles

CC(NC1=CC=C(CC2=CC=C(NC(C)=O)C=C2)C=C1)=O

Molecular Formula

C17H18N2O2

Molecular Weight

282.34

Precautions

H400

References & Citations

[1]Shan J, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nat Chem Biol. 2013 Aug;9 (8) :514-20.|[2]Lunzhi Yuan, et al. A Chimeric Humanized Mouse Model by Engrafting the Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cell for the Chronic Hepatitis B Virus Infection. Front Microbiol. 2018 May 8;9:908.|[3]Schepers AG, et al. Identification of NQO2 As a Protein Target in Small Molecule Modulation of Hepatocellular Function. ACS Chem Biol. 2021 Sep 17;16 (9) :1770-1778.