FRAX597
FRAX597 is a potent group I p21-activated Kinases (PAKs) inhibitor with IC50 of 8, 13 and 19 nM for PAK1, 2 and 3.
Product Specifications
CAS Number
1286739-19-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PAK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/FRAX597.html
Purity
99.36
Solubility
DMSO : 14.29 mg/mL (ultrasonic)
Smiles
O=C1C(C2=CC=C(C3=CN=CS3)C=C2Cl)=CC4=CN=C(NC5=CC=C(N6CCN(C)CC6)C=C5)N=C4N1CC
Molecular Formula
C29H28ClN7OS
Molecular Weight
558.10
Precautions
H302, H315, H319, H335
References & Citations
[1]Licciulli S, et al. FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2) -associated Schwannomas. J Biol Chem. 2013 Oct 4;288 (40) :29105-14.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAK1; PAK2; PAK3
Available Sizes
Frequently Asked Questions
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