FRAX597

FRAX597 is a potent group I p21-activated Kinases (PAKs) inhibitor with IC50 of 8, 13 and 19 nM for PAK1, 2 and 3.

Product Specifications

CAS Number

[1286739-19-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PAK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/FRAX597.html

Purity

99.36

Solubility

DMSO : 14.29 mg/mL (ultrasonic)

Smiles

O=C1C(C2=CC=C(C3=CN=CS3)C=C2Cl)=CC4=CN=C(NC5=CC=C(N6CCN(C)CC6)C=C5)N=C4N1CC

Molecular Formula

C29H28ClN7OS

Molecular Weight

558.10

Precautions

H302, H315, H319, H335

References & Citations

[1]Licciulli S, et al. FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2) -associated Schwannomas. J Biol Chem. 2013 Oct 4;288 (40) :29105-14.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PAK1; PAK2; PAK3

Available Sizes

Curated Selection

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