PROTAC MDM2 Degrader-1

PROTAC MDM2 Degrader-1 (Compound 15a) is a MDM2 PROTAC degrader. The structures of both Linker ends of PROTAC MDM2 Degrader-1 are MDM2 ligands. PROTAC MDM2 Degrader-1 can not only block the binding of p53-MDM2, but also degrade the target MDM2 protein by utilizing the function of the E3 ligase of MDM2 itself, thus exerting an anti-tumor effect. (Pink: MDM2 ligand 2 (HY-128836) ; Black: Linker (HY-128844) ; Blue: E3 ligase Ligand 15 (HY-128836) ) [1]

Product Specifications

CAS Number

[2249944-98-5]

UNSPSC

12352005

Target

MDM-2/p53; PROTACs

Type

Reference compound

Related Pathways

Apoptosis; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-mdm2-degrader-1.html

Purity

98.11

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N1CC(N(CC1)CC(NCCCOCCOCCOCCCNC(CN2C(CN(CC2)C(N3[C@@H](C4=CC=C(C=C4)Cl)[C@@H](C5=CC=C(C=C5)Cl)N=C3C6=C(C=C(C=C6)OC)OC(C)C)=O)=O)=O)=O)=O)N7[C@@H](C8=CC=C(C=C8)Cl)[C@@H](C9=CC=C(C=C9)Cl)N=C7C%10=C(C=C(C=C%10)OC)OC(C)C

Molecular Formula

C74H84Cl4N10O13

Molecular Weight

1463.33

References & Citations

[1]Method of inducing of self-degradation of MDM2 using E3 ubiquitin ligase dimer amide small molecule PROTACs. CN108610333A.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MDM2

Available Sizes

Curated Selection

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