PROTAC MDM2 Degrader-1
PROTAC MDM2 Degrader-1 (Compound 15a) is a MDM2 PROTAC degrader. The structures of both Linker ends of PROTAC MDM2 Degrader-1 are MDM2 ligands. PROTAC MDM2 Degrader-1 can not only block the binding of p53-MDM2, but also degrade the target MDM2 protein by utilizing the function of the E3 ligase of MDM2 itself, thus exerting an anti-tumor effect. (Pink: MDM2 ligand 2 (HY-128836) ; Black: Linker (HY-128844) ; Blue: E3 ligase Ligand 15 (HY-128836) ) [1]
Product Specifications
CAS Number
[2249944-98-5]
UNSPSC
12352005
Target
MDM-2/p53; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-mdm2-degrader-1.html
Purity
98.11
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
Molecular Formula
C74H84Cl4N10O13
Molecular Weight
1463.33
References & Citations
[1]Method of inducing of self-degradation of MDM2 using E3 ubiquitin ligase dimer amide small molecule PROTACs. CN108610333A.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MDM2
Available Sizes
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