Parsaclisib (hydrochloride)
Parsaclisib hydrochloride (INCB050465 hydrochloride) is a potent, selective and orally active inhibitor of PI3Kδ, with an IC50 of 1 nM at 1 mM ATP. Parsaclisib hydrochloride shows approximately 20000-fold selectivity over other PI3K class I isoforms. Parsaclisib hydrochloride can be used for the research of relapsed or refractory B-cell malignancies[1][2][3].
Product Specifications
CAS Number
1995889-48-9
Product Name Alternative
INCB050465 (hydrochloride) ; IBI-376 (hydrochloride)
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/parsaclisib-hydrochloride.html
Concentration
10mM
Purity
99.33
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCOC1=C([C@@H](C2)CNC2=O)C(F)=C(Cl)C=C1[C@@H](N3C4=NC=NC(N)=C4C(C)=N3)C.[H]Cl
Molecular Formula
C20H23Cl2FN6O2
Molecular Weight
469.34
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
PI3Kδ
Available Sizes
Frequently Asked Questions
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