SU14813
SU14813 is a multi-targeted receptor tyrosine kinases inhibitor with IC50s of 50, 2, 4, 15 nM for VEGFR2, VEGFR1, PDGFRβ and KIT.
Product Specifications
CAS Number
627908-92-3
UNSPSC
12352005
Hazard Statement
H315, H317, H318, H334, H335, H341, H361, H370, H413
Target
C-Kit; PDGFR; VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SU14813.html
Purity
99.11
Solubility
DMSO : 44 mg/mL (ultrasonic)
Smiles
O=C(/C(C1=C2)=C/C3=C(C(C(NC[C@H](O)CN4CCOCC4)=O)=C(N3)C)C)NC1=CC=C2F
Molecular Formula
C23H27FN4O4
Molecular Weight
442.48
Precautions
H315, H317, H318, H334, H335, H341, H361, H370, H413
References & Citations
[1]Patyna S, et al. SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity. Mol Cancer Ther. 2006 Jul;5 (7) :1774-82.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
PDGFRβ; VEGFR1/Flt-1; VEGFR2/KDR/Flk-1
Available Sizes
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