Miclxin

Miclxin (DS37262926) is a potent inhibitor of mutant β-catenin, involving in Wnt signaling pathway. Miclxin induces β-catenin-dependent apoptosis, leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targeting to MIC60, a major components of the mitochondrial contact site and cristae organizing system (MICOS) complex[1].

Product Specifications

CAS Number

[2494198-61-5]

Product Name Alternative

DS37262926

UNSPSC

12352005

Target

Apoptosis; Wnt; β-catenin

Type

Reference compound

Related Pathways

Apoptosis; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/miclxin.html

Concentration

10mM

Purity

98.12

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

COC1=CC(CNC2=C3C=CC(OC)=CC3=NC(N4CC(C5=CC=CN=C5)CC4)=N2)=CC=C1

Molecular Formula

C26H27N5O2

Molecular Weight

441.52

References & Citations

[1]Ikeda H, et al. Miclxin, a Novel MIC60 Inhibitor, Induces Apoptosis via Mitochondrial Stress in β-Catenin Mutant Tumor Cells. ACS Chem Biol. 2020 Aug 21;15 (8) :2195-2204.