Miltirone

Miltirone is an orally active natural compound found in the root of Salvia miltiorrhiza. Miltirone is a central benzodiazepine receptor partial agonist, with an IC50 of 0.3 μM. Miltirone induces ROS - and-p53 dependent apoptosis. Miltirone inhibits carboxylesterase 2 (CES2; Ki = 0.04 μM) and SARS-CoV main protease (Mpro) [1][2][3][4].

Product Specifications

CAS Number

[27210-57-7]

Product Name Alternative

Rosmariquinone

UNSPSC

12352005

Target

Apoptosis; Carboxylesterase (CES) ; GABA Receptor; SARS-CoV

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/miltirone.html

Concentration

10mM

Purity

99.74

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C(C(C)C)=CC2=C(C3=C(C=C2)C(C)(C)CCC3)C1=O

Molecular Formula

C19H22O2

Molecular Weight

282.38

References & Citations

[1]C M Lee, et al. Miltirone, a central benzodiazepine receptor partial agonist from a Chinese medicinal herb Salvia miltiorrhiza. Neurosci Lett. 1991 Jun 24;127 (2) :237-41.|[2]Wang L, et al. Miltirone induced mitochondrial dysfunction and ROS-dependent apoptosis in colon cancer cells. Life Sci. 2016 Apr 15;151:224-234.|[3]Hatfield MJ, et al. Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen") . J Nat Prod. 2013 Jan 25;76 (1) :36-44.