Tianeptine-d6 (hydrochloride)
Tianeptine-d6 hydrochloride is the deuterium labeled Tianeptine hydrochloride. Tianeptine hydrochloride is an atypical antidepressant. Tianeptine hydrochloride is a moderate-intensity agonist of the μ-opioid receptor (MOR), and to a lesser extent, is an agonist of the δ-opioid receptor (DOR) . Tianeptine hydrochloride is a glutamate modulator that can enhance AMPA receptor and antagonize NMDA receptor. Tianeptine hydrochloride increases sensitivity of the α1 adrenergic receptor, which only manifests in chronic treatment. Tianeptine hydrochloride exerts neuroprotective effects under stress/inflammation-induced conditions, exhibiting anti-inflammatory and antioxidant properties. Tianeptine hydrochloride inhibits MMP-9 by suppressing the PI3K/Akt-mediated NF-κB pathway. Tianeptine hydrochloride can be used to alleviate symptoms of depression and anxiety, but does not cause sedative effects.
Product Specifications
UNSPSC
12352005
Target
Akt; iGluR; Isotope-Labeled Compounds; MMP; NF-κB; Opioid Receptor; PI3K
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others; PI3K/Akt/mTOR
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Solubility
10 mM in DMSO
Smiles
[2H]C(CNC(C1=CC=C(Cl)C=C12)C3=CC=CC=C3N(C)S2(=O)=O)([2H])C([2H])([2H])C([2H])([2H])CCC(O)=O.Cl
Molecular Formula
C21H20D6Cl2N2O4S
Molecular Weight
479.45
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
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