GSK-3β/HDAC-IN-1
GSK-3β/HDAC-IN-1 (Compd 4) is a brain-penetrant and first in class dual non-ATP-competitive Glycogen Synthase Kinase 3β/Histone Deacetylases (GSK-3β/HDACs) Inhibitor with IC50s of 0.142, 0.03 and 0.045 μM against GSK-3β, HDAC2 and HDAC6, respectively. GSK-3β/HDAC-IN-1 can be used for Alzheimer’s disease research[1].
Product Specifications
UNSPSC
12352005
Target
GSK-3; HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gsk-3β-hdac-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NO)C1=CC=C(CN2C(SN(C3=C(C=CC=C4)C4=CC=C3)C2=O)=O)C=C1
Molecular Formula
C20H15N3O4S
Molecular Weight
393.42
References & Citations
[1]Santini A, et al. First in Class Dual Non-ATP-Competitive Glycogen Synthase Kinase 3β/Histone Deacetylase Inhibitors as a Potential Therapeutic to Treat Alzheimer's Disease. ACS Chem Neurosci. 2024 Jun 5;15 (11) :2099-2111.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3β; HDAC2; HDAC6
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