(S, R, S) -AHPC-PEG4-NH2 (hydrochloride)
(S, R, S) -AHPC-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S, R, S) -AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
Product Specifications
CAS Number
[2064292-52-8]
Product Name Alternative
VH032-PEG4-NH2 (hydrochloride) ; VHL Ligand-Linker Conjugates 4 (hydrochloride) ; E3 ligase Ligand-Linker Conjugates 7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/E3_ligase_Ligand-Linker_Conjugates_7.html
Purity
98.17
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)COCCOCCOCCOCCN.Cl
Molecular Formula
C32H50ClN5O8S
Molecular Weight
700.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Crew, Andrew P, et al. MDM2-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. US20170008904A1.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
Available Sizes
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