UK-383367
UK-383367 is an orally available pro-collagen C-protease inhibitor (BMP-1) with an IC50 value of 44 nM. UK-383367 can reduce renal fibrosis and inflammation in chronic kidney disease (CKD) and may be used to study postoperative skin scarring[1][2][3].
Product Specifications
CAS Number
348622-88-8
UNSPSC
12352005
Hazard Statement
H301
Target
Procollagen C Proteinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/UK-383367.html
Purity
99.92
Solubility
DMSO : 65 mg/mL (ultrasonic; warming)
Smiles
NC(C1=NOC([C@H](CCCC2CCCCC2)CC(NO)=O)=N1)=O
Molecular Formula
C15H24N4O4
Molecular Weight
324.38
Precautions
H301
References & Citations
[1]Allan GA, et al. Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity. Xenobiotica. 2006 May;36 (5) :399-418.|[2]Mi Bai, et al. BMP1 inhibitor UK383,367 attenuates renal fibrosis and inflammation in CKD. Am J Physiol Renal Physiol. 2019 Dec 1;317 (6) :F1430-F1438.|[3]Eugenia C Salcedo, et al. Global Protease Activity Profiling Identifies HER2-Driven Proteolysis in Breast Cancer. ACS Chem Biol. 2021 Apr 16;16 (4) :712-723.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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