UK-383367

UK-383367 is an orally available pro-collagen C-protease inhibitor (BMP-1) with an IC50 value of 44 nM. UK-383367 can reduce renal fibrosis and inflammation in chronic kidney disease (CKD) and may be used to study postoperative skin scarring[1][2][3].

Product Specifications

CAS Number

[348622-88-8]

UNSPSC

12352005

Hazard Statement

H301

Target

Procollagen C Proteinase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/UK-383367.html

Purity

99.92

Solubility

DMSO : 65 mg/mL (ultrasonic; warming)

Smiles

NC(C1=NOC([C@H](CCCC2CCCCC2)CC(NO)=O)=N1)=O

Molecular Formula

C15H24N4O4

Molecular Weight

324.38

Precautions

H301

References & Citations

[1]Allan GA, et al. Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity. Xenobiotica. 2006 May;36 (5) :399-418.|[2]Mi Bai, et al. BMP1 inhibitor UK383,367 attenuates renal fibrosis and inflammation in CKD. Am J Physiol Renal Physiol. 2019 Dec 1;317 (6) :F1430-F1438.|[3]Eugenia C Salcedo, et al. Global Protease Activity Profiling Identifies HER2-Driven Proteolysis in Breast Cancer. ACS Chem Biol. 2021 Apr 16;16 (4) :712-723.