6-Thio-2'-Deoxyguanosine
6-Thio-2'-Deoxyguanosine is a nucleoside analogue that can be incorporated into de novo-synthesized telomeres by telomerase.
Product Specifications
CAS Number
789-61-7
Product Name Alternative
6-thio-dG; β-TGdR
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/6-Thio-2_acute_-Deoxyguanosine.html
Purity
99.70
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC[C@@H]1[C@H](C[C@H](N2C=NC3=C2NC(N)=NC3=S)O1)O
Molecular Formula
C10H13N5O3S
Molecular Weight
283.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Mender I, et al. Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2'-deoxyguanosine. Cancer Discov. 2015 Jan;5 (1) :82-95.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
Frequently Asked Questions
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